Transient receptor potential ankyrin 1 (TRPA1) receptors are non-selective cation channels\nresponsive to a variety of exogenous irritants and endogenous stimuli including products of oxidative\nstress. It is mainly expressed by primary sensory neurons; however, expression of TRPA1 by astrocytes\nand oligodendrocytes has recently been detected in the mouse brain. Genetic deletion of TRPA1\nwas shown to attenuate cuprizone-induced oligodendrocyte apoptosis and myelin loss in mice.\nIn the present study we aimed at investigating mGFAP-Cre conditional TRPA1 knockout mice in the\ncuprizone model����..
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